Working with cell biologist David D. Sabatini, Blobel laid the groundwork in 1971 for what would later be known as the signal hypothesis of protein organization. The researchers suggested, and it would later be demonstrated by Blobel and others, that many peptides possess a sequence of amino acids that direct each protein to a particular target organelle. This molecular ZIP code is a critical part of the cell’s organization of molecular traffic, and its dysfunction has since been implicated in a number of diseases.
In 1999, Blobel received the Nobel Prize in Physiology or Medicine for the research, and he used the prize money to help restore a baroque Lutheran church and a synagogue as part of his work with Friends of Dresden, a charitable organization he had established several years previously. “It was one of the great pleasures of my life to donate the entire sum of the Nobel Prize, in memory of my sister Ruth Blobel, to the restoration of Dresden,” he wrote in an autobiographical sketch after receiving the award.
Over the course of his career, Blobel also received the Albert Lasker Award for Basic Medical Research in 1993 and the New York City Mayor’s Award for Excellence in Science and Technology in 1997. He held the John D. Rockefeller Jr. professorship since 1992. “His loss will be felt deeply at Rockefeller and throughout the scientific community, where he was revered for his passion for science, personal generosity and inspired leadership,” Lifton says in the statement.
Blobel is survived by his wife of more than 40 years, New York restaurant owner Laura Maioglio.